理解一下这篇文章的摘要,想想到底要不要打疫苗 |
送交者: 2021年12月22日11:52:08 于 [世界时事论坛] 发送悄悄话 |
|
题目: Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection 杂志: Nature Medicine 作者: Martina Patone et al., 2021 Although myocarditis and pericarditis were not observed as adverse events in coronavirus disease 2019 (COVID-19) vaccine trials, there have been numerous reports of suspected cases following vaccination in the general population. 尽管在 2019 年冠状病毒病 (COVID-19) 疫苗试验中未观察到心肌炎和心包炎是不良事件,但已有大量关于普通人群接种疫苗后疑似病例的报告。 We undertook a self-controlled case series study of people aged 16 or older vaccinated for COVID-19 in England between 1 December 2020 and 24 August 2021 to investigate hospital admission or death from myocarditis, pericarditis and cardiac arrhythmias in the 1–28 days following adenovirus (ChAdOx1, n = 20,615,911) or messenger RNA-based (BNT162b2, n = 16,993,389; mRNA-1273, n = 1,006,191) vaccines or a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive test (n = 3,028,867). 我们对 2020 年 12 月 1 日至 2021 年 8 月 24 日期间在英格兰接种 COVID-19 疫苗的 16 岁或以上人群进行了一项自我对照病例系列研究,以调查接种腺病毒 (ChAdOx1, n = 20,615,911) 或基于mRNA (BNT162b2, n = 16,993,389; mRNA-1273, n = 1,006,191) 冠状病毒疫苗,或SARS-CoV-2阳性 (1-28 天内)因心肌炎、心包炎和心律失常而住院或死亡。 We found increased risks of myocarditis associated with the first dose of ChAdOx1 and BNT162b2 vaccines and the first and second doses of the mRNA-1273 vaccine over the 1–28 days postvaccination period, and after a SARS-CoV-2 positive test. 我们发现,在接种后 1-28 天以及 SARS-CoV-2 阳性检测后,与第一剂 ChAdOx1 和 BNT162b2 疫苗以及第一剂和第二剂 mRNA-1273 疫苗相关的心肌炎风险增加。 We estimated an extra two, one and six myocarditis events per 1 million people vaccinated with ChAdOx1, BNT162b2 and mRNA-1273, respectively, in the 28 days following a first dose and an extra ten myocarditis events per 1 million vaccinated in the 28 days after a second dose of mRNA-1273. 我们估计每 100 万接种 ChAdOx1、BNT162b2 和 mRNA 的人中发生额外的 2 起(95% 置信区间(CI)0, 3)、1 起(95% 置信区间 0, 2)和 6 起(95% 置信区间 2, 8)心肌炎事件 (第一剂 28 天内)。第二剂 mRNA-1273 后的 28 天中,每 100 万人中发生额外 10 起心肌炎事件。 This compares with an extra 40 myocarditis events per 1 million patients in the 28 days following a SARS-CoV-2 positive test. We also observed increased risks of pericarditis and cardiac arrhythmias following a positive SARS-CoV-2 test. Similar associations were not observed with any of the COVID-19 vaccines, apart from an increased risk of arrhythmia following a second dose of mRNA-1273. Subgroup analyses by age showed the increased risk of myocarditis associated with the two mRNA vaccines was present only in those younger than 40. 相比之下,在 SARS-CoV-2 阳性检测后的 28 天内,每 100 万患者中发生额外 40 次心肌炎事件。我们还观察到在 SARS-CoV-2 检测呈阳性后发生心包炎和心律失常的风险增加。除了第二剂 mRNA-1273 后心律失常的风险增加之外,在任何 COVID-19 疫苗中均未观察到类似的关联。按年龄进行的亚组分析显示,与两种 mRNA 疫苗相关的心肌炎风险增加仅存在于 40 岁以下的人群中。 |
|
|
|
实用资讯 | |
|
|
一周点击热帖 | 更多>> |
|
|
一周回复热帖 |
|
历史上的今天:回复热帖 |
2020: | 无敌的毛主席 | |
2020: | 为人民服务 | |
2019: | 没有毛主席谁也不行! | |
2019: | 今年底全球人口将达77.5亿 1年生出1个德 | |
2018: | 老师,再这样讲历史,我就要举报你 | |
2018: | 克拉玛依的祭日 | |
2017: | “中国人民站起来了”——哪年的事? | |
2017: | 冼岩:朝鲜拥核完全正当 | |
2016: | 为什么法轮功的人劝人们三退(退党、退 | |
2016: | 中国阶层报告:顶层及最上层仅占0.001% | |
|