https://www.youtube.com/watch?v=sRaf0MZJudM
疑问2:氰化物中毒后机体会大量产生正铁血红蛋白吗?
在王首席的视屏里(见youtube连接8分30秒左右开始),她说急性氰化物中毒时机体会产生大量正铁红蛋白(或称高铁红蛋白,英文methemoglobin), 可是造成正铁血红蛋白症的病因里根本没有氰化物这一说,
Acquired methemoglobinemia is more common than the inherited forms. It occurs in some people after they are exposed to certain chemicals and drugs, including:
•Anesthetics such as benzocaine
•Benzene
•Certain antibiotics (including dapsone and chloroquine)
•Nitrites (used as additives to prevent meat from spoiling)
The condition may also occur in infants who are very ill or who are fed too many vegetables containing nitrates (such as beets).
有意思的是Nitrite(亚硝酸盐)恰恰是通过氧化血红蛋白成正铁血红蛋白而被用来治疗氰化物中毒的药物。如果氰化物可致机体产生大量正铁血红蛋白,那不就可以同时解毒了?
FDA:钠亚硝酸盐注射液用于治疗氰化物中毒获批准(http://www.bioon.com/industry/medtech/521271.shtml)